Calcium-Dependent PKC Isoforms Have Specialized Roles in Short-Term Synaptic Plasticity
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منابع مشابه
Calcium-Dependent PKC Isoforms Have Specialized Roles in Short-Term Synaptic Plasticity
Posttetanic potentiation (PTP) is a widely observed form of short-term plasticity lasting for tens of seconds after high-frequency stimulation. Here we show that although protein kinase C (PKC) mediates PTP at the calyx of Held synapse in the auditory brainstem before and after hearing onset, PTP is produced primarily by an increased probability of release (p) before hearing onset, and by an in...
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The sites of presynaptic action of calcium ions in triggering exocytosis and in activating various forms of short-term enhancement of synaptic transmission are discussed. A detailed presentation of methods and results is left to original publications. Instead, an attempt is made to collate a variety of findings and synthesize a picture of how Ca2+ operates in nerve terminals to trigger release ...
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Chemical synapses are rarely static transmitters of information between neurons. Their effectiveness waxes and wanes, depending on the frequency of stimulation and the history of prior activity. At most synapses, repetitive highfrequency action potentials (often called a tetanus) initially result in a rapid growth of successive postsynaptic potential (PSP) amplitudes, called synaptic facilitati...
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ژورنال
عنوان ژورنال: Neuron
سال: 2014
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2014.04.003